Genetic factors play important roles in the development of MDD, as indicated by family, twin, and adoption studies, and may reveal important information about disease mechanisms. Despite intensive research during the past several decades, the neurobiological basis and pathophysiology of depressive disorders remain unknown. LohoffAbstractMajor depressive disorder (MDD) is a common psychiatric illness with high levels of morbidity and mortality. Some things poison your body, your mind, your spirit.The best things you can do for yourself is to remove or reduce exposure to toxic things.Figure out what is poisoning you, and get it out of your life as best you canDepression is a symptom, not a disease.Which is why I think there is no answer to this question.Here is a good starter article cribbed from pubmed:Overview of the Genetics of Major Depressive DisorderOverview of the Genetics of Major Depressive DisorderFalk W. But, this is highly contested.However, as with most attempts to find a direct genetic link to disease, there are too many variables.It's too complex for simple answers, or simple solutions.My personal take on the subject, having had my own problems with depression, is that depression is a sign of internal toxicity.Internal toxicity can come from many sources.Toxins in food, toxic drugs, toxic environment, toxic relationships, toxic work, toxic attitudes, toxic people, toxic self loathing. that can help.Twin studies suggest 40% or so genetic linkage. Genetics, upbringing, culture, diet, stress levels, and epigenetics all play a role.I don't think you can put a firm number on it.Anyone can get depressed.The same might be said of “Resiliance”, our ability to resist having our internal homeostasis disturbed.Some people just seem better able to deal with the ups and downs.Certainly there are things we can do, like exercise, healthy diet, emotional counseling, medications, etc. What percentage of depression has been solidly linked to genetic mutations (not including polymorphisms)?The cause of depression, and other emotional maladies, is a complex interplay between nature and nurture.

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